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The mono-epoxide metabolites, 1,2-VCH epoxide, 7,8-VCH epoxide,and the diepoxide, VCd, generated by the parent compoundhave been shown to cause pre-antral follicle loss in rodentmodels. It is also modeneutral in the sense that some consequences can be produced by positive interven-tion or negative withholding of possible intervention

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